MedThink Archives

The Role Of DNA Methylation In The Pathophysiology & Treatment Of Bipolar Disorder

Article October 31, 2017

Key Messages Alterations in DNA methylation patterns in patients with bipolar disorder (BD) have a potential role in the dysregulation of gene expression and may show promise as biomarkers to… Read More

Treatment-Adherence In Bipolar Disorder: A Patient-Centred Approach

Article October 31, 2017

Key Messages Studies have shown approximately 50% of patients with bipolar disorder (BD) to be nonadherent to pharmacologic treatment. Treatment nonadherence is a multifaceted phenomenon that cannot be fully explained… Read More

Lifestyle Interventions Targeting Dietary Habits & Exercise In Bipolar Disorder: A Systematic Review

Article August 28, 2017

Key Messages A review of currently available literature indicated that patients with bipolar disorder (BD) may benefit from psychosocial interventions that adopt a multimodal strategy that goes beyond treatment adherence… Read More

Neurobiology Of Risk For Bipolar Disorder

Article July 21, 2017

Key Messages Tools that would facilitate early diagnosis, intervention, and prevention of new bipolar episodes may be of benefit to patients with bipolar disorder or who may develop bipolar disorder… Read More

Considerations In Managing Major Depressive Disorder In Patients With Comorbid Cardiovascular Disease

On-Demand Webinar July 14, 2017

Major depressive disorder (MDD) is often seen in patients with comorbid medical conditions. Selection of pharmacologic and nonpharmacological treatment options as well as other management strategies can be difficult to… Read More

Exploring Nonpharmacological Anti-Inflammatory Strategies In Mental Health: Connecting Science To Clinical Practice (Inflammation Series Part 2)

On-Demand Webinar June 15, 2017

In this second webinar in the inflammation series, Rakesh Jain, MD, MPH, along with moderator and discussant Rachel Self, MS, PhD, discuss nonpharmacologic anti-inflammatory strategies to build on the science… Read More

Empirically Supported Psychosocial Interventions For Bipolar Disorder: Current State Of The Research

Article May 18, 2017

Key Messages Although psychiatric medication is a critical component of treatment for bipolar disorder (BD), pharmacotherapy alone does not maintain most patients in remission or euthymia. In combination with medication,… Read More

Neuroprogression & Episode Recurrence In Bipolar I Disorder: A Study Of Gray Matter Volume Changes In First-Episode Mania & Association With Clinical Outcome

Article May 18, 2017

Key Messages Patients with bipolar I disorder (BD I) who experienced recurring mood episodes demonstrated decreases in gray matter volume (GMV) in certain brain regions known to regulate emotion. Changes… Read More

The Difficult Lives Of Individuals With Bipolar Disorder: A Review Of Functional Outcomes & Their Implications For Treatment

Article May 17, 2017

Key Messages Despite receiving treatment focused on resolving manic or depressive symptoms, many patients with bipolar disorder (BD) may still demonstrate impaired psychosocial functioning. The ability to fulfill expectations at… Read More

Epidemiology Of DSM-5 Bipolar I Disorder: Results From The National Epidemiologic Survey On Alcohol & Related Conditions – III

Article May 17, 2017

Key Messages When measured using diagnostic criteria from the Diagnostic and Statistical Manual of Mental Disorders-Fifth Edition, the prevalence of bipolar I disorder (BD I) was similar to previous estimates… Read More

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