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Tracking Pathophysiological Processes In Alzheimer’s Disease: An Updated Hypothetical Model Of Dynamic Biomarkers

Key Message

Temporal and sequential pattern of Alzheimer’s disease (AD) biomarkers presents a framework for in-vivo staging of disease progression.
Accumulated evidence supports the temporal and sequential patterns proposed by the original model and further modify it.


A hypothetical model of AD biomarkers proposed a framework for in-vivo staging of the disease. The model focused on established biomarkers of AD indicative of amyloid b (Ab) deposition and neurodegeneration.

The model incorporated principles based on the available data at the time.

The abnormal rate of AD …

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