Tracking Pathophysiological Processes In Alzheimer’s Disease: An Updated Hypothetical Model Of Dynamic Biomarkers
Key Message
Temporal and sequential pattern of Alzheimer’s disease (AD) biomarkers presents a framework for in-vivo staging of disease progression.
Accumulated evidence supports the temporal and sequential patterns proposed by the original model and further modify it.
Background
A hypothetical model of AD biomarkers proposed a framework for in-vivo staging of the disease. The model focused on established biomarkers of AD indicative of amyloid b (Ab) deposition and neurodegeneration.
The model incorporated principles based on the available data at the time.
The abnormal rate of AD …
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