Five Years Of Specialised Early Intervention Versus Two Years Of Specialised Early Intervention Followed By Three Years Of Standard Treatment For Patients With A First Episode Psychosis: Randomised, Superiority, Parallel Group Trial In Denmark (OPUS II)
Key Messages
Long-term follow-up studies of specialized early intervention (SEI) programs following discontinuation have been contradictory.
OPUS II was the first prolonged SEI study beyond three years.
OPUS II reported that two years of SEI (plus three years treatment as usual) or five years of continuous SEI had similar outcomes on negative symptoms (primary outcome).
Continuous SEI treatment had no significant effect on additional outcomes.
Join PsychU today at no cost for access to this and other premium content!