Welcome to PsychU!

Live Event – Agitation Associated with Alzheimer’s Dementia: Pathophysiology

Loading Events

Live Event – Agitation Associated with Alzheimer’s Dementia: Pathophysiology

This is a Live Event for PsychU members near the Fort Wayne, IN.

Tau pathology and neurodegeneration in key prefrontal and subcortical brain regions may increase the risk of developing agitation in Alzheimer’s dementia.1 Specifically, agitation in Alzheimer’s dementia may reflect an imbalance between top-down executive control (i.e., hypoactivity in prefrontal regions) and bottom-up emotional drive (i.e., hyperactivity in subcortical regions including the amygdala).1 Moreover, agitation in Alzheimer’s dementia is associated with noradrenergic, serotonergic, and dopaminergic system dysfunction in brain circuits mediating the balance between executive control and emotional drive.2,3 In this webinar, the speaker will review the loss of behavior regulation and the role of the monoamine system in the pathophysiology of agitation associated with Alzheimer’s Dementia.

1. Rosenberg, P.B., et al. Mol Aspects Med. 2015; 43-44: 25-37.

2. Jacobs, H.I., et al. Mol Psychiatry. 2021; 26(3): 897-906.

3. Lanctôt, K.L., et al. J Neuropsychiatry Clin Neurosci. 2001; 13(1): 5-21.



898 S Harrison St
Fort Wayne, IN 46802 United States
+ Google Map
(260) 459-6150 View Venue Website



Alex Matushek, PharmD, MBA (OPDC)

Medical Science Liaison

Speaker Alex Matushek PharmD., MBA is an employee of Otsuka Pharmaceutical Development & Commercialization, Inc. (OPDC)



PsychU is supported by Otsuka Pharmaceutical Developmental & Commercialization Inc., Otsuka America Pharmaceutical, Inc., and Lundbeck, L.L.C., committed supporters of the mental health treatment community; as such, PsychU is governed in accordance with the PhRMA Code on Interactions with Healthcare Professionals attendance at educational programs.


In accordance with the PhRMA Code on Interactions with Healthcare Professionals, attendance at PsychU educational programs is limited to appropriate attendees (e.g., physician, clinical professional, current medical school student, care manager, advocate, recovery coach or an executive and manager of an organization) whose primary role is to provide, manage, finance, study, or regulate mental health services for adult patients. NOTE: Otsuka Pharmaceutical Development & Commercialization Inc. (OPDC) reserves the right to decline membership to individuals who OPDC determines do not meet the certification requirements.


Membership is required to attend PsychU programs. Membership is free to all relevant mental health professionals as described above. If you are not currently a member of PsychU, you will need to become a member before you can register to attend an event. Registration for PsychU Live Events will be closed 2 business days prior to the date of the event. No walk-ins will be permitted to attend PsychU Live Events. To become a member and register for a PsychU Program, please visit https://www.PsychU.org/.


PsychU declines attendance after a healthcare professional has attended a pre-determined number of programs, has attended multiple programs on the same topic or is outside the appropriate specialty for PsychU programs, to avoid any appearance of impropriety between OPDC and the healthcare professional. This measure protects the healthcare professional as well as OPDC. If you have any questions, please do not hesitate to reach out to the OPDC Ethics and Compliance Department at E&CHelpline@otsuka-us.com.


The value of all meals provided at PsychU events will be attributed to attendees and reported in accordance with relevant federal and state laws.

Join today for instant access to all PsychU content, events, and more!

Membership is free!

Join PsychU Today to receive a wide array of tools and benefits

  • Join our multidisciplinary community that is improving mental health care… together
  • Quickly learn more about the topics you're interested in
  • Access an award-winning library of on-demand mental health resources
  • Gain key insights from industry expert & thought leaders